Fill in the form and click Estimate risk
- The y-axis shows cumulative coronary artery disease risk (%) from your current age to age 80.
- Click any point on the chart to see exact risk values and absolute risk reductions at that age.
- Each line represents a scenario:
- Blue — baseline risk (no intervention)
- Green dashed — baseline risk with cholesterol-lowering therapy (statin ± PCSK9 inhibitor)
- Yellow dashed — baseline risk reduced by antihypertensive therapy (if applicable)
- Rose dotted — combined risk reduction from all active pharmacological and/or smoking cessation interventions
- Violet dashed — projected risk if you quit smoking today (current smokers only)
- The boxes below the chart show absolute risk reduction compared to baseline at the selected age.
About this tool
For informational purposes only. This tool is intended to support discussions between patients and healthcare professionals regarding cardiovascular risk prevention — it is not intended to drive or replace clinical decision-making. Intervention effects are population-level approximations from randomized controlled trial meta-analyses, not individual causal predictions.
Optional measurements. When optional fields (waist circumference, Lp(a), CRP, or ApoB) are left blank, the model automatically selects the appropriate variant trained without those features — no imputation is performed. When ApoB is provided, it replaces non-HDL cholesterol (total cholesterol minus HDL) in the risk model. LDL is not used by the risk model. It is used only for the cholesterol-lowering intervention calculation.
Effect of interventions
- Statin: 50% LDL cholesterol reduction1 × 20% relative risk reduction per mmol/L2.
- Antihypertensive: 8% relative risk reduction per 5 mmHg if systolic blood pressure ≥ 130 mmHg3.
- Smoking cessation: −16 % risk reduction at 5 y, −31 % at 10 y, −42 % at ≥20 y (plateau)4. Current smokers only.
- PCSK9 inhibitor: 27 % relative risk reduction on top of statin therapy (VESALIUS-CV trial)5.
Relative risk reduction is proportional, not subtracted directly from your risk. For example, a 20% relative risk reduction lowers a 10% baseline risk to 8% — an absolute reduction of 2 percentage points — not to −10%.
References
